Surgeon in Ophthalmology, Massachusetts Eye and Ear Infirmary,

Assistant Clinical Professor, Harvard Medical School

Medical Director Associate Eye Physicians and Surgeons, Inc

Dr. Borodic Role in Botulinum Toxin Development

 Dr. Borodic has played a pivotal role in the development of botulinum toxin therapeutics (eg BOTOX, formerly OCCULINUM).  He has developed assays to further understand the mechanisms which govern the safe administration via laboratory experimentation and clinical experience.  His early work has been directed at understanding critical aspects of dosing which governs diffusion and control of this drug. Further work has revealed issues in formulation and preparation which influence the long term effectiveness of the treatment and the most effective administration techniques. He authored the first comprehension pharmacology chapter on the use of this drug (Chapter 10, Therapy with Botulinum Toxin, 1994 Mercel Decker - link). - PDF

Dr. Borodic directly worked with Dr. Ed Schantz and Dr. Johnson from the University of Wisconsin. Dr. Schantz initiated and championed the controlled production of the botulinum material used as a medicine.  Dr. Alan Scott, an ophthalmologist was first to use injectable botulinum toxin as a therapeutic agent. Dr. Borodic also spent educational time at the Center for Disease Control learning about the science governing handling botulinum toxin.

Dr. Borodic’s therapeutic contributions involved mastering the scientific basis for injection strategies, describing the dose response relationships, planning concepts regarding controlled administration,  uncovering initial defects in drug formulation, describing the immunity issues occurring with high dose applications, and describing the first cases treated with primary pain syndromes and headaches.

Dr. Borodic’s publications and patents have further motivated companies to produce new formulations of botulinum toxin which is currently under study and development.   

(link to Curriculum vitae)

Gary E. Borodic. MD

P: 617.770.0011
F: 617.770.0030 

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